Catherine Hardwicke’s upcoming “Miss You Already” has yet another chance in the leading role. While Toni Collette has been on board early on, her first announced co-star was Jennifer Aniston. Earlier this year, the role was replaced by Rachel Weisz. Now, Weisz has been replaced by Drew Barrymore, according to Variety. The film will also star Dominic Cooper, Paddy Considine and Jacqueline Bisset. Foreign sales at the Toronto Film Festival are being handled by The Salt Company, which shares North American sales with CAA. The film will be distributed in the United Kingdom by Entertainment One. Production will start in the U.K. on Sunday. Catherine Hardwicke directs from a screenplay by British writer and actor Morwenna Banks. Shooting is largely focused in London and later moving to the Yorkshire Moors. Collette and Barrymore portray women who have been best friends forever and Cooper and Considine play their husbands. Bisset portrays the mother of Collette’s character. The relationship hits a rough patch when Barrymore’s character struggles to have a much longed-for baby and Collette’s character finds out she has breast cancer. “‘Miss You Already’ explores the ups and down of an intense friendship,” Hardwicke said. “With our fearless actors, we’re taking this very personal story on a wild ride.”

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